Augmenting the safety and therapeutic efficacy of doxycycline and rifampicin-loaded solid lipid nanoparticles against Brucella abortus using murine model

Augmenting the safety and therapeutic efficacy of doxycycline and rifampicin-loaded solid lipid nanoparticles against Brucella abortus using murine model

Abstract Background Prolonged therapy, hepatic damage, and the development of drug resistance are the limitations of doxycycline and rifampicin in the treatment of brucellosis. This study was designed to assess the effect of solid lipid nanoparticles (SLNs) encapsulation of these antimicrobials agai...

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Bibliographic Details
Main Authors: K. M. Himani, Subbaiyan Anbazhagan, Lakshmi Prakasan, Prasad Thomas, Akhilesh Kumar, Krishnaswamy Narayanan, Praveen Singh, Pallab Chaudhuri
Format: Article
Language:English
Published: SpringerOpen 2024-12-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
Solid lipid nanoparticles
Doxycycline
Rifampicin
Brucella abortus S19
Murine model
Online Access:https://doi.org/10.1186/s43094-024-00753-8
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https://doi.org/10.1186/s43094-024-00753-8

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