Effects of dietary curcumin supplementation on the liver health of juvenile channel catfish (Ictalurus punctatus) fed high-starch diet
High-carbohydrate diet (HCD) usually leads to metabolic disorders and damages liver health in aquatic animals. Curcumin has been shown to improve antioxidant, hypoglycemic, and hypolipidemic effects. However, whether curcumin helps to ameliorate HCD-induced liver damage in fish remains unknown. Here...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Aquaculture Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352513425000018 |
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| author | Qisheng Lu Yutong Zheng Yu Wang Yulong Liu Jingyue Cao Haokun Liu Junyan Jin Zhimin Zhang Yunxia Yang Xiaoming Zhu Shouqi Xie Dong Han |
| author_facet | Qisheng Lu Yutong Zheng Yu Wang Yulong Liu Jingyue Cao Haokun Liu Junyan Jin Zhimin Zhang Yunxia Yang Xiaoming Zhu Shouqi Xie Dong Han |
| author_sort | Qisheng Lu |
| collection | DOAJ |
| description | High-carbohydrate diet (HCD) usually leads to metabolic disorders and damages liver health in aquatic animals. Curcumin has been shown to improve antioxidant, hypoglycemic, and hypolipidemic effects. However, whether curcumin helps to ameliorate HCD-induced liver damage in fish remains unknown. Here, we formulated four diets: normal-carbohydrate diet (CON), high-starch diets (HSD), 0.02 % and 0.04 % curcumin added to HSD (HSC0.02 % and HSC0.04 %) to investigate the effects of curcumin on the liver health of channel catfish (Ictalurus punctatus). The results showed that HSC0.02 % or HSC0.04 % treatments had no effect on growth performance and HSC0.02 % treatment showed the best hypoglycemic and hypolipidemic effects compared to the HSD group. Dietary curcumin activated Keap1/Nrf2 to increase hepatic antioxidant capacity (T-AOC, SOD and GSH-PX) and inhibit apoptosis pathway (Bax, Bcl2, Caspase 3 and Caspase 9) (P < 0.05). Importantly, curcumin reduces HSD-induced abnormalities of pentose phosphate pathway (PPP), triglyceride and cholesterol synthesis by inhibiting carbohydrate-responsive element-binding protein (ChREBP) expression (P < 0.05). Thus, we elucidated that curcumin ameliorates HSD-induced metabolic dysfunction and damage by inhibiting ChREBP signaling in channel catfish and assessed the feasibility of curcumin as an aquafeed additive to improve liver health in aquatic animals. |
| format | Article |
| id | doaj-art-d51183c1f7d5420fabd805f7d2e62d50 |
| institution | Kabale University |
| issn | 2352-5134 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Aquaculture Reports |
| spelling | doaj-art-d51183c1f7d5420fabd805f7d2e62d502025-02-06T05:12:19ZengElsevierAquaculture Reports2352-51342025-03-0140102615Effects of dietary curcumin supplementation on the liver health of juvenile channel catfish (Ictalurus punctatus) fed high-starch dietQisheng Lu0Yutong Zheng1Yu Wang2Yulong Liu3Jingyue Cao4Haokun Liu5Junyan Jin6Zhimin Zhang7Yunxia Yang8Xiaoming Zhu9Shouqi Xie10Dong Han11State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China; College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing 100049, ChinaState Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, ChinaState Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China; College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing 100049, ChinaState Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China; College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing 100049, ChinaState Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China; College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing 100049, ChinaState Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, ChinaState Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, ChinaState Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, ChinaState Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, ChinaState Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, ChinaState Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China; College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing 100049, China; The Innovative Academy of Seed Design, Chinese Academy of Sciences, Wuhan 430072, ChinaState Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China; College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing 100049, China; Hubei Hongshan Laboratory, Wuhan 430070, China; Corresponding author at: State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.High-carbohydrate diet (HCD) usually leads to metabolic disorders and damages liver health in aquatic animals. Curcumin has been shown to improve antioxidant, hypoglycemic, and hypolipidemic effects. However, whether curcumin helps to ameliorate HCD-induced liver damage in fish remains unknown. Here, we formulated four diets: normal-carbohydrate diet (CON), high-starch diets (HSD), 0.02 % and 0.04 % curcumin added to HSD (HSC0.02 % and HSC0.04 %) to investigate the effects of curcumin on the liver health of channel catfish (Ictalurus punctatus). The results showed that HSC0.02 % or HSC0.04 % treatments had no effect on growth performance and HSC0.02 % treatment showed the best hypoglycemic and hypolipidemic effects compared to the HSD group. Dietary curcumin activated Keap1/Nrf2 to increase hepatic antioxidant capacity (T-AOC, SOD and GSH-PX) and inhibit apoptosis pathway (Bax, Bcl2, Caspase 3 and Caspase 9) (P < 0.05). Importantly, curcumin reduces HSD-induced abnormalities of pentose phosphate pathway (PPP), triglyceride and cholesterol synthesis by inhibiting carbohydrate-responsive element-binding protein (ChREBP) expression (P < 0.05). Thus, we elucidated that curcumin ameliorates HSD-induced metabolic dysfunction and damage by inhibiting ChREBP signaling in channel catfish and assessed the feasibility of curcumin as an aquafeed additive to improve liver health in aquatic animals.http://www.sciencedirect.com/science/article/pii/S2352513425000018CurcuminCarbohydrateChREBPLiver healthChannel catfish |
| spellingShingle | Qisheng Lu Yutong Zheng Yu Wang Yulong Liu Jingyue Cao Haokun Liu Junyan Jin Zhimin Zhang Yunxia Yang Xiaoming Zhu Shouqi Xie Dong Han Effects of dietary curcumin supplementation on the liver health of juvenile channel catfish (Ictalurus punctatus) fed high-starch diet Aquaculture Reports Curcumin Carbohydrate ChREBP Liver health Channel catfish |
| title | Effects of dietary curcumin supplementation on the liver health of juvenile channel catfish (Ictalurus punctatus) fed high-starch diet |
| title_full | Effects of dietary curcumin supplementation on the liver health of juvenile channel catfish (Ictalurus punctatus) fed high-starch diet |
| title_fullStr | Effects of dietary curcumin supplementation on the liver health of juvenile channel catfish (Ictalurus punctatus) fed high-starch diet |
| title_full_unstemmed | Effects of dietary curcumin supplementation on the liver health of juvenile channel catfish (Ictalurus punctatus) fed high-starch diet |
| title_short | Effects of dietary curcumin supplementation on the liver health of juvenile channel catfish (Ictalurus punctatus) fed high-starch diet |
| title_sort | effects of dietary curcumin supplementation on the liver health of juvenile channel catfish ictalurus punctatus fed high starch diet |
| topic | Curcumin Carbohydrate ChREBP Liver health Channel catfish |
| url | http://www.sciencedirect.com/science/article/pii/S2352513425000018 |
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