A duplex one-step recombinase aided PCR assay for the rapid and sensitive detection of the isoniazid resistance genes katG and inhA in Mycobacterium tuberculosis

A duplex one-step recombinase aided PCR assay for the rapid and sensitive detection of the isoniazid resistance genes katG and inhA in Mycobacterium tuberculosis

ObjectivesDrug resistance in tuberculosis seriously affects the eradication of tuberculosis, and isoniazid resistance is the second most commonly observed drug resistance in patients with tuberculosis. Timely and accurate detection of isoniazid resistance is critical to the treatment of tuberculosis...

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Main Authors: Zhiqiang Han, Xichao Ou, Ruiqing Zhang, Xiaona Lv, Yuxin Wang, Hongyi Li, Xinxin Shen, Xuejun Ma, Yanqing Tie
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Microbiology
Subjects:
Mycobacterium tuberculosis
isoniazid resistance mutation
recombinant enzyme-assisted PCR (RAP)
locked nucleic acid technology (LNA)
highly sensitive
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1548965/full
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https://www.frontiersin.org/articles/10.3389/fmicb.2025.1548965/full

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