Inhibitory Effects of Aqueous and Hydroalcoholic Extracts from Jatobá Coat (<i>Hymenaea courbaril</i> L.) on Pancreatic Amylase and Starch Absorption
Jatobá (<i>Hymenaea courbaril</i>) is a native tree abundant in Brazil. The fruit coat is an industrial by-product of jatobá flour processing, typically discarded. Presently, within the circular bioeconomy concept, there are efforts underway that aim at finding economically viable applic...
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MDPI AG
2025-04-01
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| Online Access: | https://www.mdpi.com/2223-7747/14/7/1133 |
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| author | Ana Caroline Polo Thaís Marques Uber Gustavo Henrique Souza Rúbia Carvalho Gomes Corrêa José Rivaldo dos Santos Filho Anacharis Babeto de Sá-Nakanishi Flávio Augusto Vicente Seixas Adelar Bracht Rosane Marina Peralta |
| author_facet | Ana Caroline Polo Thaís Marques Uber Gustavo Henrique Souza Rúbia Carvalho Gomes Corrêa José Rivaldo dos Santos Filho Anacharis Babeto de Sá-Nakanishi Flávio Augusto Vicente Seixas Adelar Bracht Rosane Marina Peralta |
| author_sort | Ana Caroline Polo |
| collection | DOAJ |
| description | Jatobá (<i>Hymenaea courbaril</i>) is a native tree abundant in Brazil. The fruit coat is an industrial by-product of jatobá flour processing, typically discarded. Presently, within the circular bioeconomy concept, there are efforts underway that aim at finding economically viable applications for the bio-residues of jatobá. Within this context, the present work attempts to find possible applications for the jatobá coat in glycemic control through inhibition of α-amylase activity. Aqueous and hydroethanolic extracts were used. In vitro experiments included detailed kinetic studies with an α-amylase catalyzed reaction. Starch absorption in vivo was assessed by means of a starch tolerance test in mice. Both extracts inhibited α-amylase. The IC<sub>50</sub> values for the aqueous and hydroalcoholic extracts were 81.98 ± 3.53 µg/mL and 51.06 ± 0.42 µg/mL, respectively. The inhibition was of the non-competitive type. Both extracts reduced hyperglycemia caused by starch administration in mice, the aqueous extract being effective over a larger dose range. This action can be attributed to the α-amylase inhibition. In silico studies suggested that procyanidin dimers, taxifolin 7-O-rhamnoside, and quercetin 7-rhamnoside contribute, but several other not-yet-identified substances may be involved. The findings suggest that aqueous and hydroalcoholic extracts from jatobá coat warrant further investigations as potential modulators of glycemia following starch ingestion. |
| format | Article |
| id | doaj-art-d5012f40cd154ebfb30f52b7818fb62c |
| institution | OA Journals |
| issn | 2223-7747 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
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| series | Plants |
| spelling | doaj-art-d5012f40cd154ebfb30f52b7818fb62c2025-08-20T02:09:11ZengMDPI AGPlants2223-77472025-04-01147113310.3390/plants14071133Inhibitory Effects of Aqueous and Hydroalcoholic Extracts from Jatobá Coat (<i>Hymenaea courbaril</i> L.) on Pancreatic Amylase and Starch AbsorptionAna Caroline Polo0Thaís Marques Uber1Gustavo Henrique Souza2Rúbia Carvalho Gomes Corrêa3José Rivaldo dos Santos Filho4Anacharis Babeto de Sá-Nakanishi5Flávio Augusto Vicente Seixas6Adelar Bracht7Rosane Marina Peralta8Postgraduate Program in Food Science, State University of Maringá, Maringa 87020-900, PR, BrazilPostgraduate Program in Biochemistry, State University of Maringá, Maringa 87020-900, PR, BrazilPostgraduate Program in Biochemistry, State University of Maringá, Maringa 87020-900, PR, BrazilPostgraduate Program in Clean Technologies, Cesumar University—UNICESUMAR, Maringa 87050-390, PR, BrazilPostgraduate Program in Biochemistry, State University of Maringá, Maringa 87020-900, PR, BrazilPostgraduate Program in Food Science, State University of Maringá, Maringa 87020-900, PR, BrazilDepartment of Technology and Post-Graduate Program of Molecular and Cell Biology, State University of Maringá, Maringá 87020-900, PR, BrazilPostgraduate Program in Biochemistry, State University of Maringá, Maringa 87020-900, PR, BrazilPostgraduate Program in Food Science, State University of Maringá, Maringa 87020-900, PR, BrazilJatobá (<i>Hymenaea courbaril</i>) is a native tree abundant in Brazil. The fruit coat is an industrial by-product of jatobá flour processing, typically discarded. Presently, within the circular bioeconomy concept, there are efforts underway that aim at finding economically viable applications for the bio-residues of jatobá. Within this context, the present work attempts to find possible applications for the jatobá coat in glycemic control through inhibition of α-amylase activity. Aqueous and hydroethanolic extracts were used. In vitro experiments included detailed kinetic studies with an α-amylase catalyzed reaction. Starch absorption in vivo was assessed by means of a starch tolerance test in mice. Both extracts inhibited α-amylase. The IC<sub>50</sub> values for the aqueous and hydroalcoholic extracts were 81.98 ± 3.53 µg/mL and 51.06 ± 0.42 µg/mL, respectively. The inhibition was of the non-competitive type. Both extracts reduced hyperglycemia caused by starch administration in mice, the aqueous extract being effective over a larger dose range. This action can be attributed to the α-amylase inhibition. In silico studies suggested that procyanidin dimers, taxifolin 7-O-rhamnoside, and quercetin 7-rhamnoside contribute, but several other not-yet-identified substances may be involved. The findings suggest that aqueous and hydroalcoholic extracts from jatobá coat warrant further investigations as potential modulators of glycemia following starch ingestion.https://www.mdpi.com/2223-7747/14/7/1133diabetesα-amylase inhibitionstarch absorptionglycemiatannins |
| spellingShingle | Ana Caroline Polo Thaís Marques Uber Gustavo Henrique Souza Rúbia Carvalho Gomes Corrêa José Rivaldo dos Santos Filho Anacharis Babeto de Sá-Nakanishi Flávio Augusto Vicente Seixas Adelar Bracht Rosane Marina Peralta Inhibitory Effects of Aqueous and Hydroalcoholic Extracts from Jatobá Coat (<i>Hymenaea courbaril</i> L.) on Pancreatic Amylase and Starch Absorption Plants diabetes α-amylase inhibition starch absorption glycemia tannins |
| title | Inhibitory Effects of Aqueous and Hydroalcoholic Extracts from Jatobá Coat (<i>Hymenaea courbaril</i> L.) on Pancreatic Amylase and Starch Absorption |
| title_full | Inhibitory Effects of Aqueous and Hydroalcoholic Extracts from Jatobá Coat (<i>Hymenaea courbaril</i> L.) on Pancreatic Amylase and Starch Absorption |
| title_fullStr | Inhibitory Effects of Aqueous and Hydroalcoholic Extracts from Jatobá Coat (<i>Hymenaea courbaril</i> L.) on Pancreatic Amylase and Starch Absorption |
| title_full_unstemmed | Inhibitory Effects of Aqueous and Hydroalcoholic Extracts from Jatobá Coat (<i>Hymenaea courbaril</i> L.) on Pancreatic Amylase and Starch Absorption |
| title_short | Inhibitory Effects of Aqueous and Hydroalcoholic Extracts from Jatobá Coat (<i>Hymenaea courbaril</i> L.) on Pancreatic Amylase and Starch Absorption |
| title_sort | inhibitory effects of aqueous and hydroalcoholic extracts from jatoba coat i hymenaea courbaril i l on pancreatic amylase and starch absorption |
| topic | diabetes α-amylase inhibition starch absorption glycemia tannins |
| url | https://www.mdpi.com/2223-7747/14/7/1133 |
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