Investigation of potential toxicity associated with long-term amitriptyline exposure: Evidence from genomics

Investigation of potential toxicity associated with long-term amitriptyline exposure: Evidence from genomics

The increasing environmental detection of antidepressants such as amitriptyline (AT) has raised toxicological concerns, yet its long-term safety profile remains poorly characterized. We applied an integrative strategy combining phenome-wide association studies (PheWAS), Mendelian randomization (MR),...

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Bibliographic Details
Main Authors: Jiachen Liu, Zihan Li, Zebin Deng, Yinhuai Wang, Fei Deng
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Amitriptyline
PheWAS
Network toxicology
Mendelian randomization
Antidepressant
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325009327
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