DHODH-mediated mitochondrial redox homeostasis: a novel ferroptosis regulator and promising therapeutic target

DHODH-mediated mitochondrial redox homeostasis: a novel ferroptosis regulator and promising therapeutic target

Ferroptosis is a distinct form of regulated cell death characterized by iron-dependent lipid peroxidation, which plays a critical role in the pathogenesis of various diseases, including ischemic tissue injury, infectious diseases, neurodegenerative disorders, and cancer. The regulatory mechanisms un...

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Bibliographic Details
Main Authors: Jinghao Cao, Xi Chen, Lulu Chen, Yajuan Lu, Yunyi Wu, Aoli Deng, Feifan Pan, Hangqi Huang, Yingchao Liu, Yanchun Li, Xiangmin Tong, Jing Du
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Redox Biology
Subjects:
Dihydroorotate dehydrogenase (DHODH)
Ferroptosis
Cancer therapy
DHODH inhibitors
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725003015
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