Effect of dietary zinc supplementation on the gastrointestinal microbiome and host gene expression in the Shank3B−/− mouse model of autism spectrum disorder

Effect of dietary zinc supplementation on the gastrointestinal microbiome and host gene expression in the Shank3B−/− mouse model of autism spectrum disorder

Shank gene variants are implicated in ~1% of people with autism, and mice lacking Shank3 exhibit autism-like behaviours. Zinc deficiency and gastrointestinal problems can be common among people with autism, and zinc is a key element required for SHANK protein function and gut development. In Shank3B...

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Bibliographic Details
Main Authors: Giselle C. Wong, Yewon Jung, Kevin Lee, Chantelle Fourie, Kim M. Handley, Johanna M. Montgomery, Michael W. Taylor
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Microbiology
Subjects:
autism spectrum disorder
mouse model
Shank3
gut microbiome
host gene expression
bacteria
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1607045/full
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https://www.frontiersin.org/articles/10.3389/fmicb.2025.1607045/full

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