B cell maturation antigen (BCMA) is dispensable for the survival of long-lived plasma cells

B cell maturation antigen (BCMA) is dispensable for the survival of long-lived plasma cells

Abstract The survival of antibody-secreting plasma cells is essential for long-lasting humoral immunity. BCMA is proposed to promote APRIL-mediated survival signals. However, extensive shedding of murine BCMA raises doubts about its role as a signaling receptor. To unequivocally establish BCMA’s fun...

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Main Authors: Shannon R. Menzel, Edith Roth, Jens Wittner, Stefanie Brey, Leonie Weckwerth, Jana Thomas, Thomas H. Winkler, Wolfgang Schuh, Hans-Martin Jäck, Katharina Pracht, Sebastian R. Schulz
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62530-2
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https://doi.org/10.1038/s41467-025-62530-2

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