Role of Mitogen-Activated Protein Kinase Pathways in Multifactorial Adverse Cardiac Remodeling Associated with Metabolic Syndrome
Metabolic syndrome has been widely associated with an increased risk for acute cardiovascular events. Emerging evidence supports metabolic syndrome as a condition favoring an adverse cardiac remodeling, which might evolve towards heart dysfunction and failure. This pathological remodeling has been d...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/367245 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564572290023424 |
|---|---|
| author | Mohamed Asrih François Mach Alessio Nencioni Franco Dallegri Alessandra Quercioli Fabrizio Montecucco |
| author_facet | Mohamed Asrih François Mach Alessio Nencioni Franco Dallegri Alessandra Quercioli Fabrizio Montecucco |
| author_sort | Mohamed Asrih |
| collection | DOAJ |
| description | Metabolic syndrome has been widely associated with an increased risk for acute cardiovascular events. Emerging evidence supports metabolic syndrome as a condition favoring an adverse cardiac remodeling, which might evolve towards heart dysfunction and failure. This pathological remodeling has been described to result from the cardiac adaptive response to clinical mechanical conditions (such as hypertension, dyslipidemia, and hyperglycemia), soluble inflammatory molecules (such as cytokines and chemokines), as well as hormones (such as insulin), characterizing the pathophysiology of metabolic syndrome. Moreover, these cardiac processes (resulting in cardiac hypertrophy and fibrosis) are also associated with the modulation of intracellular signalling pathways within cardiomyocytes. Amongst the different intracellular kinases, mitogen-activated protein kinases (MAPKs) were shown to be involved in heart damage in metabolic syndrome. However, their role remains controversial. In this paper, we will discuss and update evidence on MAPK-mediated mechanisms underlying cardiac adverse remodeling associated with metabolic syndrome. |
| format | Article |
| id | doaj-art-d4bd626bc2c84bd9814ba92cbaeeb1b0 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-d4bd626bc2c84bd9814ba92cbaeeb1b02025-02-03T01:10:43ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/367245367245Role of Mitogen-Activated Protein Kinase Pathways in Multifactorial Adverse Cardiac Remodeling Associated with Metabolic SyndromeMohamed Asrih0François Mach1Alessio Nencioni2Franco Dallegri3Alessandra Quercioli4Fabrizio Montecucco5Division of Cardiology, Geneva University Hospital, Faculty of Medicine, Foundation for Medical Researches, 64 Avenue de la Roseraie, 1211 Geneva, SwitzerlandDivision of Cardiology, Geneva University Hospital, Faculty of Medicine, Foundation for Medical Researches, 64 Avenue de la Roseraie, 1211 Geneva, SwitzerlandDepartment of Internal Medicine, University of Genoa, V.le Benedetto XV 6, 16132 Genoa, ItalyFirst Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, V.le Benedetto XV 6, 16132 Genoa, ItalyDivision of Cardiology, Geneva University Hospital, Faculty of Medicine, Foundation for Medical Researches, 64 Avenue de la Roseraie, 1211 Geneva, SwitzerlandDivision of Cardiology, Geneva University Hospital, Faculty of Medicine, Foundation for Medical Researches, 64 Avenue de la Roseraie, 1211 Geneva, SwitzerlandMetabolic syndrome has been widely associated with an increased risk for acute cardiovascular events. Emerging evidence supports metabolic syndrome as a condition favoring an adverse cardiac remodeling, which might evolve towards heart dysfunction and failure. This pathological remodeling has been described to result from the cardiac adaptive response to clinical mechanical conditions (such as hypertension, dyslipidemia, and hyperglycemia), soluble inflammatory molecules (such as cytokines and chemokines), as well as hormones (such as insulin), characterizing the pathophysiology of metabolic syndrome. Moreover, these cardiac processes (resulting in cardiac hypertrophy and fibrosis) are also associated with the modulation of intracellular signalling pathways within cardiomyocytes. Amongst the different intracellular kinases, mitogen-activated protein kinases (MAPKs) were shown to be involved in heart damage in metabolic syndrome. However, their role remains controversial. In this paper, we will discuss and update evidence on MAPK-mediated mechanisms underlying cardiac adverse remodeling associated with metabolic syndrome.http://dx.doi.org/10.1155/2013/367245 |
| spellingShingle | Mohamed Asrih François Mach Alessio Nencioni Franco Dallegri Alessandra Quercioli Fabrizio Montecucco Role of Mitogen-Activated Protein Kinase Pathways in Multifactorial Adverse Cardiac Remodeling Associated with Metabolic Syndrome Mediators of Inflammation |
| title | Role of Mitogen-Activated Protein Kinase Pathways in Multifactorial Adverse Cardiac Remodeling Associated with Metabolic Syndrome |
| title_full | Role of Mitogen-Activated Protein Kinase Pathways in Multifactorial Adverse Cardiac Remodeling Associated with Metabolic Syndrome |
| title_fullStr | Role of Mitogen-Activated Protein Kinase Pathways in Multifactorial Adverse Cardiac Remodeling Associated with Metabolic Syndrome |
| title_full_unstemmed | Role of Mitogen-Activated Protein Kinase Pathways in Multifactorial Adverse Cardiac Remodeling Associated with Metabolic Syndrome |
| title_short | Role of Mitogen-Activated Protein Kinase Pathways in Multifactorial Adverse Cardiac Remodeling Associated with Metabolic Syndrome |
| title_sort | role of mitogen activated protein kinase pathways in multifactorial adverse cardiac remodeling associated with metabolic syndrome |
| url | http://dx.doi.org/10.1155/2013/367245 |
| work_keys_str_mv | AT mohamedasrih roleofmitogenactivatedproteinkinasepathwaysinmultifactorialadversecardiacremodelingassociatedwithmetabolicsyndrome AT francoismach roleofmitogenactivatedproteinkinasepathwaysinmultifactorialadversecardiacremodelingassociatedwithmetabolicsyndrome AT alessionencioni roleofmitogenactivatedproteinkinasepathwaysinmultifactorialadversecardiacremodelingassociatedwithmetabolicsyndrome AT francodallegri roleofmitogenactivatedproteinkinasepathwaysinmultifactorialadversecardiacremodelingassociatedwithmetabolicsyndrome AT alessandraquercioli roleofmitogenactivatedproteinkinasepathwaysinmultifactorialadversecardiacremodelingassociatedwithmetabolicsyndrome AT fabriziomontecucco roleofmitogenactivatedproteinkinasepathwaysinmultifactorialadversecardiacremodelingassociatedwithmetabolicsyndrome |