A<sub>2A</sub> Adenosine Receptor Antagonists and Their Efficacy in Rat Models of Parkinson’s Disease

A<sub>2A</sub> Adenosine Receptor Antagonists and Their Efficacy in Rat Models of Parkinson’s Disease

Parkinson’s disease (PD) represents a growing challenge to global health, as it involves millions of people. The high grade of disability is due to the loss of dopaminergic neuron activity, and levodopa is the gold-standard therapy used to restore dopamine in the dopamine-denervated regions. Another...

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Bibliographic Details
Main Authors: Andrea Spinaci, Michela Buccioni, Diego Dal Ben, Beatrice Francucci, Karl-Norbert Klotz, Gabriella Marucci, Nicola Simola, Micaela Morelli, Annalisa Pinna, Rosaria Volpini, Catia Lambertucci
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Cells
Subjects:
adenosine receptor ligands
adenosine receptor antagonists
synthesis of purine derivatives
binding and functional assays
<i>in vivo</i> models of Parkinson’s disease
medicinal chemistry
Online Access:https://www.mdpi.com/2073-4409/14/5/338
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