MAVS signaling of long-lived brain-resident myeloid cells is needed during viral encephalitis to adjust the transcriptome of CNS infiltrating CD8+ T cells

MAVS signaling of long-lived brain-resident myeloid cells is needed during viral encephalitis to adjust the transcriptome of CNS infiltrating CD8+ T cells

Abstract Neurotropic viruses like vesicular stomatitis virus (VSV) can infect the central nervous system (CNS) through the olfactory route. Following intranasal instillation, VSV moves along the axons of olfactory sensory neurons to the olfactory bulb. While within the olfactory bulb the spread of t...

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Main Authors: Andreas Pavlou, Luca Ghita, Felix Mulenge, Inken Waltl, Olivia Luise Gern, Pia-Katharina Larsen, Bibiana Costa, Veronica Duran, Lena Mareike Busker, Shelly J. Robertson, Yvonne Lueder, Stephan Halle, Reinhold Förster, Sonja M. Best, Martin Stangel, Ulrich Kalinke
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
CD8+ T cells
Brain infection
Cross-presentation
CNS
MAVS signaling
Online Access:https://doi.org/10.1186/s12974-025-03497-1
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https://doi.org/10.1186/s12974-025-03497-1

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