Cdkn1a silencing restores myoblast differentiation by inducing selective apoptosis in senescent cells

Cdkn1a silencing restores myoblast differentiation by inducing selective apoptosis in senescent cells

Abstract Background Sarcopenia, characterized by a progressive loss of skeletal muscle mass and function, is associated with the accumulation of senescent muscle stem cells, which impair muscle regeneration and contributes to the decline in muscle health. Cdkn1a, which encodes p21, is a well-known m...

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Main Authors: Sujin Kim, Bonsang Gu, Chan-Young So, Keren Esther Kristina Mantik, Seung-Hyun Jung, Sohee Moon, Dong-Ho Park, Hyo-Bum Kwak, Jinkyung Cho, Eun-Jeong Cho, Jae-Seon Lee, Ju-Hee Kang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Cellular & Molecular Biology Letters
Subjects:
p21
Cdkn1a
Senescence
Sarcopenia
Senolysis
Myogenesis
Online Access:https://doi.org/10.1186/s11658-025-00731-9
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https://doi.org/10.1186/s11658-025-00731-9

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