Single cell RNA sequencing analysis of mice hindlimb muscles identifies transcriptional heterogeneity in aging and physical frailty

Single cell RNA sequencing analysis of mice hindlimb muscles identifies transcriptional heterogeneity in aging and physical frailty

Abstract Frailty, a geriatric syndrome, is characterized by the age-related deterioration of physical capabilities and multiple organ systems. However, its age-associated and age-independent mechanisms remain vague, impeding prevention and clinical intervention. Here, the physical frailty status of...

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Bibliographic Details
Main Authors: Minwen Jie, Tong Feng, Fengjuan Hu, Xuelian Sun, Shuli Jia, Yanrong Lu, Birong Dong, Hao Jiang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Frailty
Single-cell RNA-seq
Relatively healthy aging
Age-associated frailty
Age-independent frailty
Online Access:https://doi.org/10.1038/s41598-025-10421-3
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https://doi.org/10.1038/s41598-025-10421-3

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