O-GlcNAc-modified HOXA9 suppresses ferroptosis via promoting UBR5-mediated SIRT6 degradation in nasopharyngeal carcinoma

O-GlcNAc-modified HOXA9 suppresses ferroptosis via promoting UBR5-mediated SIRT6 degradation in nasopharyngeal carcinoma

Background: Nasopharyngeal carcinoma (NPC) is the most common malignancy of the nasopharynx. Ferroptosis induction shows anti-tumor activities in cancers including NPC. Elucidating the regulatory mechanism of ferroptosis is crucial for developing targeted therapeutic strategies for NPC. Methods: The...

Full description

Saved in:

Bibliographic Details
Main Authors:	Huai Liu, Yingzhou Fu, Ling Tang, Bo Song, Wangning Gu, Hongmin Yang, Tengfei Xiao, Hui Wang, Pan Chen
Format:	Article
Language:	English
Published:	Elsevier 2025-04-01
Series:	Neoplasia: An International Journal for Oncology Research
Subjects:	Nasopharyngeal carcinoma Ferroptosis HOXA9 UBR5 SIRT6 O-GlcNAcylation
Online Access:	http://www.sciencedirect.com/science/article/pii/S1476558625000211
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Rescuable sleep and synaptogenesis phenotypes in a Drosophila model of O-GlcNAc transferase intellectual disability
by: Ignacy Czajewski, et al.
Published: (2024-11-01)

O-GlcNAcylation dictates pyroptosis
by: Yue Lang, et al.
Published: (2024-12-01)

Curcumin promotes spermatogenesis in mice with cryptorchidism by regulating testicular protein O-GlcNAcylation
by: Zhen Wang, et al.
Published: (2025-06-01)

Hypoxia‐Induced O‐GlcNAcylation of GATA3 Leads to Excessive Testosterone Production in Preeclamptic Placentas
by: Juan Liu, et al.
Published: (2025-03-01)

Sex alters thyroid hormone’s effect on protein O-GlcNAcylation in the aged mouse heart
by: Aaron K. Olson, et al.
Published: (2025-06-01)

FTO O-GlcNAcylation promotes TRIM21-mediated FTO ubiquitination degradation to sustain the negative feedback control of macrophage inflammation
by: Lu Zhang, et al.
Published: (2025-06-01)

Migrasome Marker Epidermal Growth Factor Domain-Specific <i>O</i>-GlcNAc Transferase: Pan-Cancer Angiogenesis Biomarker and the Potential Role of circ_0058189/miR-130a-3p/EOGT Axis in Hepatocellular Carcinoma Progression and Sorafenib Resistance
by: Zhe Yu, et al.
Published: (2025-03-01)

OGT-induced O-GlcNAcylation of NEK7 protein aggravates osteoarthritis progression by enhancing NEK7/NLRP3 axis
by: Chunlei He, et al.
Published: (2024-12-01)

Discovery and clinical translation of ceperognastat, an O‐GlcNAcase (OGA) inhibitor, for the treatment of Alzheimer's disease
by: William Kielbasa, et al.
Published: (2024-10-01)

GALNT6 associated with O-GlcNAcylation contributes to the tumorigenesis of oral squamous cell carcinoma
by: Junfeng Yan, et al.
Published: (2025-07-01)

Inhibition of O‐GlcNAcylation protects from Shiga toxin‐mediated cell injury and lethality in host
by: Kyung‐Soo Lee, et al.
Published: (2021-11-01)

O-GlcNAcylation with ubiquitination stabilizes METTL3 to promoting HMGB1 degradation to inhibit ferroptosis and enhance gemcitabine resistance in pancreatic cancer
by: Qiuhong Wang, et al.
Published: (2025-06-01)

O-GlcNAcylation-related genes mediate tumor microenvironment characteristics and prediction of immunotherapy response in gastric cancer
by: Wang Wangwen, et al.
Published: (2024-12-01)

Regulation of the expression of ferrochelatase in a murine model of diabetes mellitus type I
by: Leda María Oliveri, et al.
Published: (2025-06-01)

OGA promotes human dental pulp stem cell senescence and inhibits mitophagy by inhibition of O-GlcNAcylation of KLF2
by: Yinhao Ding, et al.
Published: (2025-04-01)

Decoding glycosylation in cardiovascular diseases: mechanisms, biomarkers, and therapeutic opportunities
by: Gang Li, et al.
Published: (2025-05-01)

<i>O</i>-GlcNAcylation of Focal Adhesion Kinase Regulates Cell Adhesion, Migration, and Proliferation via the FAK/AKT Pathway
by: Zhiwei Zhang, et al.
Published: (2024-12-01)

LEP O-GlcNAcylation inactivates NF-κB pathway by suppressing LEP protein level and thus mediates cellular senescence and osteogenic differentiation in mouse mesenchymal stem cells
by: Zhuang Zhang, et al.
Published: (2024-12-01)

HCF-1 as a key modulator of OGT function and O-GlcNAcylation in the liver
by: Vaibhav Kapuria, et al.
Published: (2025-08-01)

Switch of phosphorylation to O-GlcNAcylation of AhR contributes to vascular oxidative stress induced by benzo[a]pyrene
by: Rong Wang, et al.
Published: (2023-11-01)

Galectin-3: Integrator of Signaling via Hexosamine Flux
by: Mana Mohan Mukherjee, et al.
Published: (2025-07-01)

A glutathione-responsive ferroptotic inducer with elevated labile iron pool and self-supplied peroxide for chemodynamic therapy
by: Penghui Wei, et al.
Published: (2025-06-01)

Genistein inhibits HIF-1α and attenuates high glucose-induced peritoneal mesothelial-mesenchymal transition and fibrosis via the mTOR/OGT pathway
by: Jian Wang, et al.
Published: (2024-10-01)

SIRT5‐mediated HOXA5 desuccinylation inhibits ferroptosis to alleviate sepsis induced‐lung injury
by: Lei Wang, et al.
Published: (2025-01-01)

Cardiac LXRα protects against pathological cardiac hypertrophy and dysfunction by enhancing glucose uptake and utilization
by: Megan V Cannon, et al.
Published: (2015-07-01)

Estrogen inhibits hepatocellular carcinoma progression dependent on HOXA11-AS/HOXA11
by: Pincheng Zhou, et al.
Published: (2025-07-01)

Twist1-induced suppression of oncogene-induced senescence in non-small cell lung cancer requires the transactivation domain of Twist1
by: Audrey Lafargue, et al.
Published: (2025-08-01)

New perspectives on YTHDF2 O-GlcNAc modification in the pathogenesis of intervertebral disc degeneration
by: Liangjie Lu, et al.
Published: (2024-10-01)

Functional genomic profiling of O-GlcNAc reveals its context-specific interplay with RNA polymerase II
by: Sofia Rucli, et al.
Published: (2025-03-01)

Proximity Labeling-Based Identification of MGAT3 Substrates and Revelation of the Tumor-Suppressive Role of Bisecting GlcNAc in Breast Cancer via GLA Degradation
by: Bowen Wang, et al.
Published: (2025-01-01)

Identification of HOXA9 methylation as an epigenetic biomarker predicting prognosis and guiding treatment choice in acute myeloid leukemia
by: Fei Xie, et al.
Published: (2025-02-01)

The role of long non-coding ribonucleic acid HOXA11-AS in endometriosis therapy
by: Ramanaiah Mamillapalli, et al.
Published: (2025-06-01)

Association between O-GlcNAc transferase activity and major adverse cardiovascular events: findings from the China PEACE-MPP cohort
by: Wei Yu, et al.
Published: (2025-04-01)

SMAD4 promotes EMT in COPD airway remodeling induced by cigarette smoke through interaction with O-GlcNAc transferase
by: Ziteng Wang, et al.
Published: (2024-10-01)

Bisecting GlcNAc enhances CD8+ T cell-mediated killing of breast cancer by suppressing PD-L1 expression and its binding to PD-1
by: Xueting Ren, et al.
Published: (2025-08-01)

Linking O-GlcNAc and intron retention
by: John A Hanover
Published: (2025-05-01)

Improved VPS4B O-GlcNAc modification triggers lipid droplets transferring from adipocytes to nasopharyngeal carcinoma cells
by: Haimeng Yin, et al.
Published: (2025-05-01)

TUBERCULOSIS CASE MODEL USING GCV AND UBR KNOT SELECTION METHODS IN TRUNCATED SPLINE NONPARAMETRIC REGRESSION
by: Sitti Anggraeni, et al.
Published: (2023-09-01)

Loss of Hoxa5 function affects Hox gene expression in different biological contexts
by: Béatrice Frenette, et al.
Published: (2024-12-01)

Proteomic identification of the UDP-GlcNAc: PI α1-6 GlcNAc-transferase subunits of the glycosylphosphatidylinositol biosynthetic pathway of Trypanosoma brucei.
by: Zhe Ji, et al.
Published: (2021-01-01)