O-GlcNAc-modified HOXA9 suppresses ferroptosis via promoting UBR5-mediated SIRT6 degradation in nasopharyngeal carcinoma

Background: Nasopharyngeal carcinoma (NPC) is the most common malignancy of the nasopharynx. Ferroptosis induction shows anti-tumor activities in cancers including NPC. Elucidating the regulatory mechanism of ferroptosis is crucial for developing targeted therapeutic strategies for NPC. Methods: The...

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Bibliographic Details
Main Authors: Huai Liu, Yingzhou Fu, Ling Tang, Bo Song, Wangning Gu, Hongmin Yang, Tengfei Xiao, Hui Wang, Pan Chen
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Neoplasia: An International Journal for Oncology Research
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Online Access:http://www.sciencedirect.com/science/article/pii/S1476558625000211
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