Ranolazine as a therapeutic agent for diabetic cardiomyopathy: reducing endoplasmic reticulum stress and inflammation in type 2 diabetic rat model

Abstract Background Diabetic cardiomyopathy (DCM) is a significant cardiovascular complication of diabetes, characterized by structural and functional heart muscle dysfunction. Oxidative stress, endoplasmic reticulum (ER) stress, and inflammation are pivotal in the pathogenesis of DCM. Ranolazine, p...

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Bibliographic Details
Main Authors: Matin Mohyadini, Aghele Fahimi, S. Zahra Bathaie, Hamid Yaghooti
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Pharmacology and Toxicology
Subjects:
Online Access:https://doi.org/10.1186/s40360-025-00945-9
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