Identifying nexilin as a central gene in neutrophil-driven abdominal aortic aneurysm pathogenesis

Identifying nexilin as a central gene in neutrophil-driven abdominal aortic aneurysm pathogenesis

Abstract Objectives Abdominal aortic aneurysm (AAA) is an inflammation-driven disease in which neutrophil infiltration is critical to its progression. This study aims to explore the molecular mechanisms behind neutrophil infiltration in AAA and identify key regulatory genes. Methods We utilized weig...

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Bibliographic Details
Main Authors: Bohan Yang, Yiyan Xu, Fengfei Yan, Cheng Peng, Ye Song, Song Han, Haiyang Wang
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Molecular Medicine
Subjects:
Abdominal aortic aneurysm
Neutrophils
Weighted gene co-expression network analysis
Nexilin
Immune cell infiltration
Machine learning
Online Access:https://doi.org/10.1186/s10020-025-01157-x
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https://doi.org/10.1186/s10020-025-01157-x

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