Beyond gold: the chemoenhancing mechanism and therapeutic potential of auranofin in melanoma

Beyond gold: the chemoenhancing mechanism and therapeutic potential of auranofin in melanoma

Objective: The objective of the current study was to evaluate the chemosensitizing capacity of auranofin (AF), a gold (I) complex traditionally used in rheumatoid arthritis treatment, in potentiating the cytotoxic effects of doxorubicin (DOX) in melanoma cell models, specifically drug-sensitive (B16...

Full description

Saved in:

Bibliographic Details
Main Authors:	Xiaofeng Wang, Yingnan Liu, Wuqiong Zhang, Zhongda Li, Su Li, Jiaxin Chen, Qi Li, Xiaoman Suo, Yanqiao Zeng, Guofang Zhang, Yang Li
Format:	Article
Language:	English
Published:	China Anti-Cancer Association 2025-06-01
Series:	Cancer Biology & Medicine
Subjects:	auranofin trxr1 anti-cancer drug resistance molecular dynamics simulation
Online Access:	https://www.cancerbiomed.org/content/22/6/672
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Comparison of the mechanism of antimicrobial action of the gold(I) compound auranofin in Gram-positive and Gram-negative bacteria
by: Laísa Quadros Barsé, et al.
Published: (2024-11-01)

The gold complex auranofin sensitizes platinum resistant epithelial ovarian cancer cells to cisplatin
by: Farah H. Abdalbari, et al.
Published: (2025-06-01)

Repurposing auranofin combined with colistin to effectively combat fish-pathogenic Edwardsiella piscicida
by: Jinfang Lu, et al.
Published: (2025-07-01)

Auranofin amplifies schisandrin A-induced apoptosis through ROS generation and inhibiting the PI3K/Akt pathway in hepatocellular carcinoma
by: Hyun Hwangbo, et al.
Published: (2025-06-01)

Auranofin inhibition of thioredoxin reductase sensitizes lung neuroendocrine tumor cells (NETs) and small cell lung cancer (SCLC) cells to sorafenib as well as inhibiting SCLC xenograft growth
by: Spenser S. Johnson, et al.
Published: (2024-12-01)

Searching for New Gold(I)-Based Complexes as Anticancer and/or Antiviral Agents
by: Paola Checconi, et al.
Published: (2025-04-01)

A dual inhibitor of TrxR1 and XIAP induces pyroptosis in melanoma
by: Yuan Wang, et al.
Published: (2025-05-01)

Micheliolide Alleviates Hepatic Fibrosis by Inhibiting Autophagy in Hepatic Stellate Cells via the TrxR1/2-Mediated ROS/MEK/ERK Pathway
by: Yi Liu, et al.
Published: (2025-02-01)

Correlation between selenium levels and selenoproteins expression in idiopathic generalized epilepsy: a study from Karachi
by: Hareem Nisar, et al.
Published: (2025-01-01)

A CD Study of a Structure-Based Selection of <i>N</i>-Heterocyclic Bis-Carbene Gold(I) Complexes as Potential Ligands of the G-Quadruplex-Forming Human Telomeric hTel23 Sequence
by: Maria Marzano, et al.
Published: (2024-11-01)

Evaluating the amoeba thioredoxin reductase selenoprotein as potential drug target for treatment of Acanthamoeba infections
by: Alvie Loufouma-Mbouaka, et al.
Published: (2024-12-01)

Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis.
by: Christina A Bulman, et al.
Published: (2015-02-01)

Auranofin is active against Histoplasma capsulatum and reduces the expression of virulence-related genes.
by: Marcos de Abreu Almeida, et al.
Published: (2024-10-01)

Ligand supplementation restores the cancer therapy efficacy of the antirheumatic drug auranofin from serum inactivation
by: Yuan Wang, et al.
Published: (2025-08-01)

Biologically synthesized green gold nanoparticles from Siberian ginseng induce growth-inhibitory effect on melanoma cells (B16)
by: Fenglian Wu, et al.
Published: (2019-12-01)

cGAS/STING in skin melanoma: from molecular mechanisms to therapeutics
by: Jafaridarabjerdi Mahin, et al.
Published: (2024-11-01)

Natural products as therapeutics for malignant melanoma: preclinical evidence and mechanism
by: Hongjin Gao, et al.
Published: (2025-08-01)

Tyrosinase inhibitors as melanoma sensitizers: Boosting therapeutic efficacy
by: Yongsheng Li, et al.
Published: (2025-12-01)

Numb and NumbL inhibit melanoma tumor growth by influencing the immune microenvironment
by: Siyu Zhang, et al.
Published: (2024-11-01)

Editorial: Advanced therapeutic strategies in digestive and circulatory health: nanomedicine and beyond
by: Dan Li, et al.
Published: (2025-07-01)

Melanoma genomics – will we go beyond BRAF in clinics?
by: Justyna Mirek, et al.
Published: (2024-09-01)

Genetic and transcriptional insights into immune checkpoint blockade response and survival: lessons from melanoma and beyond
by: Jiaxin Wen, et al.
Published: (2025-04-01)

Programmed cell death-driven remodeling of the melanoma microenvironment enables prognostic stratification and therapeutic prediction
by: Bo Hu, et al.
Published: (2025-08-01)

Correction: Melanoma genomics– will we go beyond BRAF in clinics?
by: Justyna Mirek, et al.
Published: (2025-02-01)

Seeing beyond the obvious: Choroidal melanoma in a case of glaucoma
by: Anju Liza Zachariah, et al.
Published: (2025-07-01)

An Anisotropic Gold‐Palladium Heterostructured Nanosystem for Synergistically Overcoming Radioresistance and Enhancing Melanoma Radioimmunotherapy
by: Cheng Chen, et al.
Published: (2025-08-01)

GOLD(I)-BASED COMPLEX AUDMAP: A PROMISING ANTIPROLIFERATIVE AGENT FOR MELANOMA TREATMENT
by: Isabela Carvalho Diniz, et al.
Published: (2025-05-01)

Multiple Roles for VEGF in Non-Melanoma Skin Cancer: Angiogenesis and Beyond
by: Kelly E. Johnson, et al.
Published: (2012-01-01)

Photosensitizing Activity of Nanoparticles of Poly (2-amino phenol)/Gold for Intensified Doxorubicin Therapeutic Effect on Melanoma Cancer Cells under Synergism Effect of 808-nm Light
by: Naghmeh Sattarahmady, et al.
Published: (2024-12-01)

Antifibrotic drugs as therapeutic tools in resistant melanoma
by: Berta Sanchez‐Laorden, et al.
Published: (2022-02-01)

Gold Nanoparticles in Nanomedicine: Unique Properties and Therapeutic Potential
by: Furkan Eker, et al.
Published: (2024-11-01)

Aβ aggregation inhibition via peptide-conjugated gold nanoclusters: Mechanistic insights and therapeutic potential
by: Ye-Cheng Wang, et al.
Published: (2025-06-01)

Radiosensitising effect of iron oxide‐gold nanocomplex for electron beam therapy of melanoma in vivo by magnetic targeting
by: Mahshad Mohamadkazem, et al.
Published: (2023-05-01)

Beyond the glitter: gold nanoparticles as powerful weapons against multi-drug resistant pathogens
by: Hazim O. Khalifa, et al.
Published: (2025-08-01)

Interaction of Oligonucleotides with Gold Nanoparticles: Factors Beyond Electrostatic and Van‐Der Waals Forces
by: Shaila Thakur, et al.
Published: (2025-07-01)

Targeting the Cellular Signaling: BRAF Inhibition and Beyond for the Treatment of Metastatic Malignant Melanoma
by: Felipe Ades, et al.
Published: (2012-01-01)

DNA methylation in melanoma immunotherapy: mechanisms and therapeutic opportunities
by: Maya G. Deshmukh, et al.
Published: (2025-04-01)

Potential of CLSPN as a therapeutic target in melanoma: a key player in melanoma progression and tumor microenvironment
by: Yongyi Xie, et al.
Published: (2025-04-01)

Metabolic reprogramming in melanoma therapy
by: Dongliang Shen, et al.
Published: (2025-07-01)

Nanotechnology in brain cancer treatment: The role of gold nanoparticles as therapeutic enhancers
by: Simona Tarantino, et al.
Published: (2025-06-01)