Aminoacyl-tRNA synthetase urzymes optimized by deep learning behave as a quasispecies

Protein design plays a key role in our efforts to work out how genetic coding began. That effort entails urzymes. Urzymes are small, conserved excerpts from full-length aminoacyl-tRNA synthetases that remain active. Urzymes require design to connect disjoint pieces and repair naked nonpolar patches...

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Bibliographic Details
Main Authors: Sourav Kumar Patra, Nicholas Randolph, Brian Kuhlman, Henry Dieckhaus, Laurie Betts, Jordan Douglas, Peter R. Wills, Charles W. Carter Jr.
Format: Article
Language:English
Published: AIP Publishing LLC and ACA 2025-03-01
Series:Structural Dynamics
Online Access:http://dx.doi.org/10.1063/4.0000294
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