PGC-1 alpha overexpression in the skeletal muscle results in a metabolically active microbiome which is independent of redox signaling

PGC-1 alpha overexpression in the skeletal muscle results in a metabolically active microbiome which is independent of redox signaling

Abstract In this study, we investigated the potential relationship between the mitochondrial network and the microbiome using wild-type and skeletal muscle-specific PGC-1α (Pparg coactivator 1 alpha) overexpressing mice, both with and without exercise training. Basal PGC-1α levels were significantly...

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Bibliographic Details
Main Authors: Erika Koltai, Soroosh Mozaffaritabar, Lei Zhou, Attila Kolonics, Atsuko Koike, Kumpei Tanisawa, Jonguk Park, Ferenc Torma, Zsolt Radak
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Mitochondria
Microbiota
PGC-1α
Physical exercise
Host–microbial interaction
Online Access:https://doi.org/10.1038/s41598-025-05594-w
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