Decreased Expression of Thyroglobulin and Sodium Iodide Symporter Genes in Hashimoto’s Thyroiditis
Aim. The aim of the study was to compare the expression of sodium iodide symporter (NIS), thyroglobulin (Tg), tumor necrosis factor-α (TNFα), and interleukin-1β genes in patients with Hashimoto’s thyroiditis (HT) and healthy individuals. Subjects and Methods. Thyroid cells were obtained from 39 pati...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/690704 |
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| author | Anna Popławska-Kita Beata Telejko Katarzyna Siewko Maria Kościuszko-Zdrodowska Natalia Wawrusewicz-Kurylonek Adam Krętowski Justyna Hryniewicka Janusz Dzięcioł Witold Bauer Robert Milewski Małgorzata Szelachowska Maria Górska |
| author_facet | Anna Popławska-Kita Beata Telejko Katarzyna Siewko Maria Kościuszko-Zdrodowska Natalia Wawrusewicz-Kurylonek Adam Krętowski Justyna Hryniewicka Janusz Dzięcioł Witold Bauer Robert Milewski Małgorzata Szelachowska Maria Górska |
| author_sort | Anna Popławska-Kita |
| collection | DOAJ |
| description | Aim. The aim of the study was to compare the expression of sodium iodide symporter (NIS), thyroglobulin (Tg), tumor necrosis factor-α (TNFα), and interleukin-1β genes in patients with Hashimoto’s thyroiditis (HT) and healthy individuals. Subjects and Methods. Thyroid cells were obtained from 39 patients with HT and 15 controls by an ultrasound guided fine needle aspiration biopsy. Results. The patients with HT had lower Tg and NIS mRNA (P=0.002 and P=0.001, resp.), as well as higher TNFα mRNA expression (P=0.049) than the controls. In the HT group Tg mRNA expression correlated positively with NIS mRNA expression (R=0.739, P=0.0001) and thyroid volume (R=0.465, P=0.0005), as well as negatively with TNFα mRNA expression (R=-0.490, P=0.001) and anti-peroxidase antibodies (TPOAb) level (R=-0.482, P=0.0002), whereas NIS mRNA expression correlated positively with thyroid volume (R=0.319, P=0.02), as well as negatively with TNFα mRNA expression (R=-0.529, P=0.0006) and TPOAb level (R=-0.422, P=0.001). Conclusions. Our results suggest that decreased Tg and NIS expression in thyroid cells may result in reduced active iodide transport and reduced thyroid volume in patients with HT. |
| format | Article |
| id | doaj-art-d47317171fc64384b1f23f454e395ecc |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-d47317171fc64384b1f23f454e395ecc2025-02-03T06:06:12ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/690704690704Decreased Expression of Thyroglobulin and Sodium Iodide Symporter Genes in Hashimoto’s ThyroiditisAnna Popławska-Kita0Beata Telejko1Katarzyna Siewko2Maria Kościuszko-Zdrodowska3Natalia Wawrusewicz-Kurylonek4Adam Krętowski5Justyna Hryniewicka6Janusz Dzięcioł7Witold Bauer8Robert Milewski9Małgorzata Szelachowska10Maria Górska11Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Sklodowskiej-Curie 24A, 15-276 Bialystok, PolandDepartment of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Sklodowskiej-Curie 24A, 15-276 Bialystok, PolandDepartment of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Sklodowskiej-Curie 24A, 15-276 Bialystok, PolandDepartment of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Sklodowskiej-Curie 24A, 15-276 Bialystok, PolandDepartment of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Sklodowskiej-Curie 24A, 15-276 Bialystok, PolandDepartment of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Sklodowskiej-Curie 24A, 15-276 Bialystok, PolandDepartment of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Sklodowskiej-Curie 24A, 15-276 Bialystok, PolandDepartment of Human Anatomy, Medical University of Bialystok, Mickiewicza 2A, 15-230 Białystok, PolandCentre for Clinical Research, Medical University of Bialystok, J. Waszyngtona 15A, 15-276, PolandDepartment of Statistics and Medical Informatics, Medical University of Bialystok, Szpitalna 37, 15-295 Białystok, PolandDepartment of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Sklodowskiej-Curie 24A, 15-276 Bialystok, PolandDepartment of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Sklodowskiej-Curie 24A, 15-276 Bialystok, PolandAim. The aim of the study was to compare the expression of sodium iodide symporter (NIS), thyroglobulin (Tg), tumor necrosis factor-α (TNFα), and interleukin-1β genes in patients with Hashimoto’s thyroiditis (HT) and healthy individuals. Subjects and Methods. Thyroid cells were obtained from 39 patients with HT and 15 controls by an ultrasound guided fine needle aspiration biopsy. Results. The patients with HT had lower Tg and NIS mRNA (P=0.002 and P=0.001, resp.), as well as higher TNFα mRNA expression (P=0.049) than the controls. In the HT group Tg mRNA expression correlated positively with NIS mRNA expression (R=0.739, P=0.0001) and thyroid volume (R=0.465, P=0.0005), as well as negatively with TNFα mRNA expression (R=-0.490, P=0.001) and anti-peroxidase antibodies (TPOAb) level (R=-0.482, P=0.0002), whereas NIS mRNA expression correlated positively with thyroid volume (R=0.319, P=0.02), as well as negatively with TNFα mRNA expression (R=-0.529, P=0.0006) and TPOAb level (R=-0.422, P=0.001). Conclusions. Our results suggest that decreased Tg and NIS expression in thyroid cells may result in reduced active iodide transport and reduced thyroid volume in patients with HT.http://dx.doi.org/10.1155/2014/690704 |
| spellingShingle | Anna Popławska-Kita Beata Telejko Katarzyna Siewko Maria Kościuszko-Zdrodowska Natalia Wawrusewicz-Kurylonek Adam Krętowski Justyna Hryniewicka Janusz Dzięcioł Witold Bauer Robert Milewski Małgorzata Szelachowska Maria Górska Decreased Expression of Thyroglobulin and Sodium Iodide Symporter Genes in Hashimoto’s Thyroiditis International Journal of Endocrinology |
| title | Decreased Expression of Thyroglobulin and Sodium Iodide Symporter Genes in Hashimoto’s Thyroiditis |
| title_full | Decreased Expression of Thyroglobulin and Sodium Iodide Symporter Genes in Hashimoto’s Thyroiditis |
| title_fullStr | Decreased Expression of Thyroglobulin and Sodium Iodide Symporter Genes in Hashimoto’s Thyroiditis |
| title_full_unstemmed | Decreased Expression of Thyroglobulin and Sodium Iodide Symporter Genes in Hashimoto’s Thyroiditis |
| title_short | Decreased Expression of Thyroglobulin and Sodium Iodide Symporter Genes in Hashimoto’s Thyroiditis |
| title_sort | decreased expression of thyroglobulin and sodium iodide symporter genes in hashimoto s thyroiditis |
| url | http://dx.doi.org/10.1155/2014/690704 |
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