A novel taxane SB-T-101141 triggers a noncanonical ferroptosis to overcome Paclitaxel resistance of breast cancer via iron homeostasis-related KHSRP

A novel taxane SB-T-101141 triggers a noncanonical ferroptosis to overcome Paclitaxel resistance of breast cancer via iron homeostasis-related KHSRP

Abstract Acquired multidrug resistance impedes the clinical application of paclitaxel. Here, we disclosed that the taxane SB-T-101141 efficiently contributed to a novel ferroptosis-like cell death of Paclitaxel-resistant and parental breast cancer cells. Functionally, SB-T-101141 facilitated the pro...

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Main Authors: Xiaomei Zhang, Ying Fang, Dade Rong, Jie Li, Zhe Li, Huidan Qiu, Qiuxia Chen, Jing Yang, Changwei Wang, Junxiu Huang, Qin Zhao, Shulan Yang, Haihe Wang
Format: Article
Language:English
Published: Nature Publishing Group 2025-05-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07710-0
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https://doi.org/10.1038/s41419-025-07710-0

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