Gasdermin D is activated but does not drive neurodegeneration in SOD1G93A model of ALS: Implications for targeting pyroptosis

Gasdermin D is activated but does not drive neurodegeneration in SOD1G93A model of ALS: Implications for targeting pyroptosis

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor neuron loss, microgliosis, and neuroinflammation. While pyroptosis, an inflammatory form of programmed cell death, has been implicated in ALS, the specific role of Gasdermin D (GSDMD) - the pr...

Full description

Saved in:
Bibliographic Details
Main Authors: Georgia Gunner, Himanish Basu, Yueting Lu, Matthew Bergstresser, Liwei Sun, Dylan Neel, So Yoen Choi, Isaac M. Chiu
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Neurobiology of Disease
Subjects:
ALS
Microglia
Pyroptosis
Gasdermin D
Neuroimmunology
Cell death
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125002645
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S0969996125002645

Similar Items