Unveiling genetic signatures of immune response in immune-related diseases through single-cell eQTL analysis across diverse conditions

Unveiling genetic signatures of immune response in immune-related diseases through single-cell eQTL analysis across diverse conditions

Abstract Deciphering the intricate regulatory mechanisms underlying biological processes holds promise for elucidating how genetic variants contribute to immune-related disorders. We map genetic effects on gene expression (expression quantitative trait locus, eQTL) using single-cell transcriptomes o...

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Main Authors: Zhenhua Zhang, Wenchao Li, Qiuyao Zhan, Michelle Aillaud, Javier Botey-Bataller, Martijn Zoodsma, Rob ter Horst, Leo A. B. Joosten, Christoph Bock, Leon N. Schulte, Cheng-Jian Xu, Mihai G. Netea, Marc Jan Bonder, Yang Li
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61192-4
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https://doi.org/10.1038/s41467-025-61192-4

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