Large-Scale Preparation of (S)-α-Methylmethionine from the Parent Amino Acid
The sodium salt of methionine is treated with pivalaldehyde to give an imine which is cyclized to an 1,3-oxazolidin-5-one by treatment with benzoyl chloride. The 2,4-cis-substituted heterocycle (6) is isolated by crystallization, methylated through the Li-enolate, and hydrolyzed to give the title c...
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| Main Authors: | , |
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| Format: | Article |
| Language: | deu |
| Published: |
Swiss Chemical Society
1988-04-01
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| Series: | CHIMIA |
| Online Access: | https://www.chimia.ch/chimia/article/view/9845 |
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