DNMT3A triggers tumorigenesis of non-small cell lung cancer through regulation of SLIT2 methylation and SLIT2-mediated macrophage M1/M2 polarization

Background: Increased DNA methylation is prevalent in human cancers and is one of the important characteristics of tumors. This research aims to investigate the molecular mechanisms that involve DNMT3A and DNA methylation modification of SLIT2 in non-small cell lung cancer (NSCLC). Methods: Gene exp...

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Bibliographic Details
Main Authors: Tian-xing Ni, Jia-bo Shen
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Molecular and Cellular Probes
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Online Access:http://www.sciencedirect.com/science/article/pii/S089085082500026X
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