Characterization of growth differentiation factor 15 (GDF15) as a neurotropic adipokine permeable to the brain

Characterization of growth differentiation factor 15 (GDF15) as a neurotropic adipokine permeable to the brain

Abstract GDF15 (growth/differentiation factor-15) belongs to the superfamily of transforming growth factor-beta. Little is known about adipocytic regulation of GDF15, its concentrations in serum and cerebrospinal fluid (CSF), its permeability to the brain, and its correlation with neurological disea...

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Bibliographic Details
Main Authors: Andreas Schmid, Emily Wilfurth, Alexandra Höpfinger, Manuel Behrendt, Edita Islami, Thomas Karrasch, Martin Berghoff, Andreas Schäffler
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
GDF15
Cerebrospinal fluid
Fat-Brain axis
Adipocyte
Adipose tissue
Adipokine
Online Access:https://doi.org/10.1038/s41598-025-14846-8
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https://doi.org/10.1038/s41598-025-14846-8

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