Anticancer activity of RM-3-22: a TAZQ-based hydroxamic acid derivative targeting NSCLC in vitro and in vivo

Anticancer activity of RM-3-22: a TAZQ-based hydroxamic acid derivative targeting NSCLC in vitro and in vivo

IntroductionLung cancer remains the leading cause of cancer-related deaths, necessitating novel therapeutic strategies. In this study, we developed RM-3-22, a TAZQ-based hydroxamic acid derivative with histone deacetylase (HDAC) inhibitory properties. We evaluated its anticancer activity in non-smal...

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Main Authors: Essha Chatterjee, Ram Sharma, Biswajit Dey, Hoshiyar Singh, Aliva Naik, Anjesh Khan, Santanu Basak, Ankush Bansode, Ritika Sachdeva, Anamika Sharma, Rahul Kumar, Pradeep Naik, Pankaj Kumar Singh, Kunal Nepali, Santosh Kumar Guru
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
apoptosis
autophagy
cell cycle arrest
cell death
PI3K/Akt/mTOR pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1544666/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1544666/full

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