SITA: Predicting site-specific immunogenicity for therapeutic antibodies

SITA: Predicting site-specific immunogenicity for therapeutic antibodies

Antibody humanization is critical to reduce immunogenicity and enhance efficacy in the preclinical phase of the development of therapeutic antibodies originated from animal models. Computational suggestions have long been desired, but available tools focused on immunogenicity calculation of whole an...

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Bibliographic Details
Main Authors: Yewei Cun, Hao Ding, Tiantian Mao, Yuan Wang, Caicui Wang, Jiajun Li, Zihao Li, Mengdie Hu, Zhiwei Cao, Tianyi Qiu
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Machine learning
Therapeutic antibody
Immunogenicity
Humanization
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177925001339
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