Targeting YAP to overcome acquired resistance to ALK inhibitors in ALK‐rearranged lung cancer

Targeting YAP to overcome acquired resistance to ALK inhibitors in ALK‐rearranged lung cancer

Abstract Clinical benefit of ALK tyrosine kinase inhibitors (ALK‐TKIs) in ALK‐rearranged lung cancer has been limited by the inevitable development of acquired resistance, and bypass‐molecular resistance mechanisms remain poorly understood. We investigated a novel therapeutic target through screenin...

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Main Authors: Mi Ran Yun, Hun Mi Choi, You Won Lee, Hyeong Seok Joo, Chae Won Park, Jae Woo Choi, Dong Hwi Kim, Han Na Kang, Kyoung‐Ho Pyo, Eun Joo Shin, Hyo Sup Shim, Ross A Soo, James Chih‐Hsin Yang, Sung Sook Lee, Hyun Chang, Min Hwan Kim, Min Hee Hong, Hye Ryun Kim, Byoung Chul Cho
Format: Article
Language:English
Published: Springer Nature 2019-10-01
Series:EMBO Molecular Medicine
Subjects:
acquired resistance
ALK
non‐small cell lung cancer
statin
YAP
Online Access:https://doi.org/10.15252/emmm.201910581
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https://doi.org/10.15252/emmm.201910581

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