NGR‐Modified CAF‐Derived exos Targeting Tumor Vasculature to Induce Ferroptosis and Overcome Chemoresistance in Osteosarcoma

NGR‐Modified CAF‐Derived exos Targeting Tumor Vasculature to Induce Ferroptosis and Overcome Chemoresistance in Osteosarcoma

Abstract Osteosarcoma (OS) chemoresistance presents a significant clinical challenge. This study aims to investigate the potential of using tumor vascular‐targeting peptide NGR‐modified cancer‐associated fibroblasts (CAFs)‐derived exosomes (exos) to deliver circ_0004872‐encoded small peptides promot...

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Bibliographic Details
Main Authors: Jianxin Du, Xiangwei Meng, Minghao Yang, Guancheng Chen, Jigang Li, Zengjun Zhu, Xuanxuan Wu, Wei Hu, Maojin Tian, Tao Li, Shuai Ren, Peiqing Zhao
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
cancer‐associated fibroblasts
circ_0004872‐109aa
circ_0004872
NGR
NGR‐109aa‐Exos
Osteosarcoma
Online Access:https://doi.org/10.1002/advs.202410918
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https://doi.org/10.1002/advs.202410918

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