Disruption of hnRNP A2-mediated RNA dynamics by amyloid-β drives MBP increase in Alzheimer’s disease

Disruption of hnRNP A2-mediated RNA dynamics by amyloid-β drives MBP increase in Alzheimer’s disease

Abstract Oligodendrocyte dysfunction, myelin degeneration, and white matter changes are critical events in the cognitive decline of Alzheimer’s disease (AD). Amyloid-β peptide (Aβ), a hallmark of AD, disrupts oligodendrocyte and myelin homeostasis, through mechanisms that remain poorly understood. H...

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Main Authors: Adhara Gaminde-Blasco, Rodrigo Senovilla-Ganzo, Uxue Balantzategi, Maialen Martinez-Preciado, Estibaliz Capetillo-Zarate, Fernando García-Moreno, Carlos Matute, Jimena Baleriola, Elena Alberdi
Format: Article
Language:English
Published: Springer 2025-08-01
Series:Cellular and Molecular Life Sciences
Subjects:
Oligodendrocytes
MBP
HnRNP A2
Calcium homeostasis
Amyloid-β peptide
Alzheimer´s disease
Online Access:https://doi.org/10.1007/s00018-025-05823-5
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https://doi.org/10.1007/s00018-025-05823-5

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