Superparamagnetic Bifunctional Bisphosphonates Nanoparticles: A Potential MRI Contrast Agent for Osteoporosis Therapy and Diagnostic
A bone targeting nanosystem is reported here which combined magnetic contrast agent for Magnetic Resonance Imaging (MRI) and a therapeutic agent (bisphosphonates) into one drug delivery system. This new targeting nanoplatform consists of superparamagnetic γFe2O3 nanoparticles conjugated to 1,5-dihy...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Journal of Osteoporosis |
| Online Access: | http://dx.doi.org/10.4061/2010/747852 |
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| author | Y. Lalatonne M. Monteil H. Jouni J. M. Serfaty O. Sainte-Catherine N. Lièvre S. Kusmia P. Weinmann M. Lecouvey L. Motte |
| author_facet | Y. Lalatonne M. Monteil H. Jouni J. M. Serfaty O. Sainte-Catherine N. Lièvre S. Kusmia P. Weinmann M. Lecouvey L. Motte |
| author_sort | Y. Lalatonne |
| collection | DOAJ |
| description | A bone targeting nanosystem is reported here which combined magnetic contrast agent for Magnetic Resonance Imaging (MRI) and a therapeutic agent (bisphosphonates) into one drug delivery system. This new targeting nanoplatform consists of superparamagnetic γFe2O3 nanoparticles conjugated to 1,5-dihydroxy-1,5,5-tris-phosphono-pentyl-phosphonic acid (di-HMBPs) molecules with a bisphosphonate function at the outer of the nanoparticle surface for bone targeting. The as-synthesized nanoparticles were evaluated as a specific MRI contrast agent by adsorption study onto hydroxyapatite and MRI measurment. The strong adsorption of the bisphosphonates nanoparticles to hydroxyapatite and their use as MRI T2∗ contrast agent were demonstrated. Cellular tests performed on human osteosarcoma cells (MG63) show that γFe2O3@di-HMBP hybrid nanomaterial has no citoxity effect in cell viability and may act as a diagnostic and therapeutic system. |
| format | Article |
| id | doaj-art-d3fa92bc77864f8f9e3afc6c46b950bd |
| institution | Kabale University |
| issn | 2042-0064 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Osteoporosis |
| spelling | doaj-art-d3fa92bc77864f8f9e3afc6c46b950bd2025-02-03T01:23:47ZengWileyJournal of Osteoporosis2042-00642010-01-01201010.4061/2010/747852747852Superparamagnetic Bifunctional Bisphosphonates Nanoparticles: A Potential MRI Contrast Agent for Osteoporosis Therapy and DiagnosticY. Lalatonne0M. Monteil1H. Jouni2J. M. Serfaty3O. Sainte-Catherine4N. Lièvre5S. Kusmia6P. Weinmann7M. Lecouvey8L. Motte9Laboratoire CSPBAT, C2B, FRE 3043 CNRS, Université Paris 13, 93017 Bobigny Cedex, FranceLaboratoire CSPBAT, C2B, FRE 3043 CNRS, Université Paris 13, 93017 Bobigny Cedex, FranceLaboratoire CSPBAT, C2B, FRE 3043 CNRS, Université Paris 13, 93017 Bobigny Cedex, FranceService de Radiologie, Hôpital Bichat, APHP, U 698 ISERM, Université Paris 7, 75877 Paris Cedex 18, FranceLaboratoire CSPBAT, C2B, FRE 3043 CNRS, Université Paris 13, 93017 Bobigny Cedex, FranceUPRES 3410 Biothérapies Bénéfices et Risques, Université Paris 13, 93017 Bobigny Cedex, FrancePlateforme d'IRM du Petit Animal, U 970 INSERM, Université Paris 5, 75908 Paris Cedex 10, FranceService de Médecine Nucléaire, Hôpital Avicenne, APHP, 93009 Bobigny Cedex, FranceLaboratoire CSPBAT, C2B, FRE 3043 CNRS, Université Paris 13, 93017 Bobigny Cedex, FranceLaboratoire CSPBAT, C2B, FRE 3043 CNRS, Université Paris 13, 93017 Bobigny Cedex, FranceA bone targeting nanosystem is reported here which combined magnetic contrast agent for Magnetic Resonance Imaging (MRI) and a therapeutic agent (bisphosphonates) into one drug delivery system. This new targeting nanoplatform consists of superparamagnetic γFe2O3 nanoparticles conjugated to 1,5-dihydroxy-1,5,5-tris-phosphono-pentyl-phosphonic acid (di-HMBPs) molecules with a bisphosphonate function at the outer of the nanoparticle surface for bone targeting. The as-synthesized nanoparticles were evaluated as a specific MRI contrast agent by adsorption study onto hydroxyapatite and MRI measurment. The strong adsorption of the bisphosphonates nanoparticles to hydroxyapatite and their use as MRI T2∗ contrast agent were demonstrated. Cellular tests performed on human osteosarcoma cells (MG63) show that γFe2O3@di-HMBP hybrid nanomaterial has no citoxity effect in cell viability and may act as a diagnostic and therapeutic system.http://dx.doi.org/10.4061/2010/747852 |
| spellingShingle | Y. Lalatonne M. Monteil H. Jouni J. M. Serfaty O. Sainte-Catherine N. Lièvre S. Kusmia P. Weinmann M. Lecouvey L. Motte Superparamagnetic Bifunctional Bisphosphonates Nanoparticles: A Potential MRI Contrast Agent for Osteoporosis Therapy and Diagnostic Journal of Osteoporosis |
| title | Superparamagnetic Bifunctional Bisphosphonates Nanoparticles: A Potential MRI Contrast Agent for Osteoporosis Therapy and Diagnostic |
| title_full | Superparamagnetic Bifunctional Bisphosphonates Nanoparticles: A Potential MRI Contrast Agent for Osteoporosis Therapy and Diagnostic |
| title_fullStr | Superparamagnetic Bifunctional Bisphosphonates Nanoparticles: A Potential MRI Contrast Agent for Osteoporosis Therapy and Diagnostic |
| title_full_unstemmed | Superparamagnetic Bifunctional Bisphosphonates Nanoparticles: A Potential MRI Contrast Agent for Osteoporosis Therapy and Diagnostic |
| title_short | Superparamagnetic Bifunctional Bisphosphonates Nanoparticles: A Potential MRI Contrast Agent for Osteoporosis Therapy and Diagnostic |
| title_sort | superparamagnetic bifunctional bisphosphonates nanoparticles a potential mri contrast agent for osteoporosis therapy and diagnostic |
| url | http://dx.doi.org/10.4061/2010/747852 |
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