Understanding the role of obesity in endocrine therapy for postmenopausal breast cancer: significance of the BIG 1–98 and ATAC trial data
Abstract Obesity is a known risk factor for poor breast cancer outcomes, but its impact on endocrine therapy efficacy remains unclear. While the ATAC trial suggests reduced effectiveness of aromatase inhibitors (AIs) in women with obesity, the BIG 1–98 trial found no significant differences. Clinica...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Springer
2025-07-01
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| Series: | Discover Oncology |
| Online Access: | https://doi.org/10.1007/s12672-025-02857-w |
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| _version_ | 1849334647452860416 |
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| author | Sixten Harborg Signe Borgquist |
| author_facet | Sixten Harborg Signe Borgquist |
| author_sort | Sixten Harborg |
| collection | DOAJ |
| description | Abstract Obesity is a known risk factor for poor breast cancer outcomes, but its impact on endocrine therapy efficacy remains unclear. While the ATAC trial suggests reduced effectiveness of aromatase inhibitors (AIs) in women with obesity, the BIG 1–98 trial found no significant differences. Clinical and biological evidence indicates that obesity may impair AI efficacy by increasing aromatase activity and altering drug metabolism, whereas tamoxifen remains largely unaffected. Pooling data from these trials would enable detailed analyses across body composition categories, addressing discrepancies and potentially guide personalized treatment strategies. Understanding the interaction between obesity and endocrine therapy is crucial for optimizing breast cancer care. |
| format | Article |
| id | doaj-art-d3f6f915f874402abd8a18fd0b1afdc7 |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-d3f6f915f874402abd8a18fd0b1afdc72025-08-20T03:45:31ZengSpringerDiscover Oncology2730-60112025-07-011611510.1007/s12672-025-02857-wUnderstanding the role of obesity in endocrine therapy for postmenopausal breast cancer: significance of the BIG 1–98 and ATAC trial dataSixten Harborg0Signe Borgquist1Department of Oncology, Aarhus University, Aarhus University HospitalDepartment of Oncology, Aarhus University, Aarhus University HospitalAbstract Obesity is a known risk factor for poor breast cancer outcomes, but its impact on endocrine therapy efficacy remains unclear. While the ATAC trial suggests reduced effectiveness of aromatase inhibitors (AIs) in women with obesity, the BIG 1–98 trial found no significant differences. Clinical and biological evidence indicates that obesity may impair AI efficacy by increasing aromatase activity and altering drug metabolism, whereas tamoxifen remains largely unaffected. Pooling data from these trials would enable detailed analyses across body composition categories, addressing discrepancies and potentially guide personalized treatment strategies. Understanding the interaction between obesity and endocrine therapy is crucial for optimizing breast cancer care.https://doi.org/10.1007/s12672-025-02857-w |
| spellingShingle | Sixten Harborg Signe Borgquist Understanding the role of obesity in endocrine therapy for postmenopausal breast cancer: significance of the BIG 1–98 and ATAC trial data Discover Oncology |
| title | Understanding the role of obesity in endocrine therapy for postmenopausal breast cancer: significance of the BIG 1–98 and ATAC trial data |
| title_full | Understanding the role of obesity in endocrine therapy for postmenopausal breast cancer: significance of the BIG 1–98 and ATAC trial data |
| title_fullStr | Understanding the role of obesity in endocrine therapy for postmenopausal breast cancer: significance of the BIG 1–98 and ATAC trial data |
| title_full_unstemmed | Understanding the role of obesity in endocrine therapy for postmenopausal breast cancer: significance of the BIG 1–98 and ATAC trial data |
| title_short | Understanding the role of obesity in endocrine therapy for postmenopausal breast cancer: significance of the BIG 1–98 and ATAC trial data |
| title_sort | understanding the role of obesity in endocrine therapy for postmenopausal breast cancer significance of the big 1 98 and atac trial data |
| url | https://doi.org/10.1007/s12672-025-02857-w |
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