Understanding the role of obesity in endocrine therapy for postmenopausal breast cancer: significance of the BIG 1–98 and ATAC trial data

Abstract Obesity is a known risk factor for poor breast cancer outcomes, but its impact on endocrine therapy efficacy remains unclear. While the ATAC trial suggests reduced effectiveness of aromatase inhibitors (AIs) in women with obesity, the BIG 1–98 trial found no significant differences. Clinica...

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Bibliographic Details
Main Authors: Sixten Harborg, Signe Borgquist
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Discover Oncology
Online Access:https://doi.org/10.1007/s12672-025-02857-w
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