Nidogen-1 suppresses cell proliferation, migration, and glycolysis via integrin β1-mediated HIF-1α downregulation in triple-negative breast cancer

Nidogen-1 suppresses cell proliferation, migration, and glycolysis via integrin β1-mediated HIF-1α downregulation in triple-negative breast cancer

Abstract Nidogen-1 (NID1) is a secreted glycoprotein widely distributed in basement membranes. NID1 interacts with extracellular matrix proteins such as collagen and laminin and has been implicated in the progression of various cancers. However, study on the role of NID1 in breast cancer is scarce a...

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Bibliographic Details
Main Authors: Joo-hyung Lee, Seogho Son, Yunhyo Ko, Hogeun Lim, Minhyeok Lee, Min-gyeong Kang, Hyungjoo Kim, Kyung-min Lee, Incheol Shin
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Breast cancer
NID1
Glycolysis
HIF1α
TNBC
Online Access:https://doi.org/10.1038/s41598-024-84880-5
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https://doi.org/10.1038/s41598-024-84880-5

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