Modeling and Simulation of Acetaminophen Pharmacokinetics and Hepatic Biomarkers After Overdoses of Extended‐Release and Immediate‐Release Formulations in Healthy Adults Using the Quantitative Systems Toxicology Software Platform DILIsym

Modeling and Simulation of Acetaminophen Pharmacokinetics and Hepatic Biomarkers After Overdoses of Extended‐Release and Immediate‐Release Formulations in Healthy Adults Using the Quantitative Systems Toxicology Software Platform DILIsym

ABSTRACT Acetaminophen (APAP) has been formulated as immediate‐, modified‐, and extended‐release tablets (APAP‐IR, ‐MR, and ‐ER, respectively). However, there was concern that APAP‐MR previously available in Europe could form a bezoar after a large overdose, leading to delayed absorption and atypica...

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Main Authors: James J. Beaudoin, Kyunghee Yang, Brett A. Howell, Zackary Kenz, Vinal V. Lakhani, Jeffrey L. Woodhead, John C. K. Lai, Cathy K. Gelotte, Sury Sista, Evren Atillasoy
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:CPT: Pharmacometrics & Systems Pharmacology
Subjects:
acetaminophen
DILIsym
GastroPlus
hepatotoxicity
modeling and simulation
paracetamol
Online Access:https://doi.org/10.1002/psp4.13304
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https://doi.org/10.1002/psp4.13304

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