Modeling non-hereditary mechanisms of Alzheimer disease during apoptosis in yeast

Modeling non-hereditary mechanisms of Alzheimer disease during apoptosis in yeast

Impaired protein degradation and mitochondrial dysfunction are believed to contribute to neurodegenerative disorders, including Alzheimer disease (AD). In patients suffering from non-hereditary AD, UBB+1, the frameshift variant of ubiquitin B, accumulated in neurons affected by neurofi...

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Bibliographic Details
Main Authors: Ralf J. Braun, Cornelia Sommer, Christine Leibiger, Romina J.G. Gentier, Verónica I. Dumit, Katrin Paduch, Tobias Eisenberg, Lukas Habernig, Gert Trausinger, Christoph Magnes, Thomas Pieber, Frank Sinner, Jörn Dengjel, Fred W. van Leeuwen, Guido Kroemer, Frank Madeo
Format: Article
Language:English
Published: Shared Science Publishers OG 2015-03-01
Series:Microbial Cell
Subjects:
Alzheimer’s disease
ubiquitin
proteasome
UBB+1
Cdc48
Vms1
ANKZF1
ZNF744
mitochondria
basic amino acids
arginine
ornithine
lysine
Saccharomyces cerevisiae
apoptosis
necrosis
programmed cell death
Online Access:http://microbialcell.com/researcharticles/modeling-non-hereditary-mechanisms-of-alzheimer-disease-during-apoptosis-in-yeast/
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