TAF2 condensation in nuclear speckles links basal transcription factor TFIID to RNA splicing factors

TAF2 condensation in nuclear speckles links basal transcription factor TFIID to RNA splicing factors

Summary: TFIID is an essential basal transcription factor, crucial for RNA polymerase II (pol II) promoter recognition and transcription initiation. The TFIID complex consists of the TATA binding protein (TBP) and 13 TBP-associated factors (TAFs) that contain intrinsically disordered regions (IDRs)...

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Main Authors: Tanja Bhuiyan, Niccolò Arecco, Paulina Karen Mendoza Sanchez, Juhyeong Kim, Carsten Schwan, Sophie Weyrauch, Sheikh Nizamuddin, Andrea Prunotto, Mehmet Tekman, Martin L. Biniossek, Bettina Knapp, Stefanie Koidl, Friedel Drepper, Pitter F. Huesgen, Robert Grosse, Thorsten Hugel, Sebastian J. Arnold
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Cell Reports
Subjects:
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725003870
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