Unique target binding by the C-terminal region of FHR1 provides a new perception of aHUS pathology

Unique target binding by the C-terminal region of FHR1 provides a new perception of aHUS pathology

IntroductionFHR1 is a multifunctional human plasma protein with three C-terminal domains, namely short consensus repeats (SCR) 3–5, showing 98% sequence-identity with the complement inhibitor Factor H. We show that FHR1 uses all three C-terminal SCR to make surface contact. The conserved C-terminal...

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Bibliographic Details
Main Authors: Luce Perie, Selina Stippa, Christoph Saffer, Andrea Hartmann, Mathias Mörgelin, Svante L. H. Zipfel, Marc Thilo Figge, Thorsten Wiech, Christine Skerka, Peter F. Zipfel
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Hematology
Subjects:
complement
FHR1
complement hemolysis
hemolytic uremic syndrome
FHR1 Factor H balance at surfaces
Online Access:https://www.frontiersin.org/articles/10.3389/frhem.2024.1469176/full
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https://www.frontiersin.org/articles/10.3389/frhem.2024.1469176/full

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