Maternal Western-style diet has a persistent effect on offspring gene expression in skeletal muscle of Japanese macaques

Maternal Western-style diet has a persistent effect on offspring gene expression in skeletal muscle of Japanese macaques

Abstract The cellular mechanisms underlying a greater risk of cardiometabolic disease in adult offspring exposed to maternal obesity are not known. Our prior work found reduced skeletal muscle mitochondrial metabolism and insulin sensitivity in offspring exposed to maternal (m) Western-style diet (W...

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Main Authors: Emily A. Beck, Byron Hetrick, Luis Nassar, Douglas W. Turnbull, Tyler A. Dean, Diana L. Takahashi, Maureen Gannon, Stephanie R. Wesolowski, Kjersti M. Aagaard, Jacob E. Friedman, Paul Kievit, Carrie E. McCurdy
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Metabolic programming
Maternal diet
Offspring
Skeletal muscle
Gene expression
Maternal obesity
Online Access:https://doi.org/10.1038/s41598-025-00828-3
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https://doi.org/10.1038/s41598-025-00828-3

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