Ether lipids and sphingolipids drive sex-specific human aging dynamics

Ether lipids and sphingolipids drive sex-specific human aging dynamics

Aging is a dynamic process characterized by complex molecular changes, including shifts in lipid metabolism. To systematically define lipidome dynamics with age and identify sex-specific lipidomic signatures, we performed targeted lipidomic profiling of plasma samples from 1030 adults aged 50–98 yea...

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Main Authors: Joaquim Sol, Anna Fernàndez-Bernal, Natalia Mota-Martorell, Meritxell Martín-Garí, Èlia Obis, Alba Juanes, Victoria Ayala, Jordi Mayneris-Perxachs, Rafel Ramos, Víctor Pineda, Josep Garre-Olmo, Manuel Portero-Otín, José Manuel Fernández-Real, Josep Puig, Mariona Jové, Reinald Pamplona
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Redox Biology
Subjects:
Aging dynamics
Aging crests
Metabolic adaptation
Lipid metabolism
Sex-specific lipidomics
Ether-linked phospholipids
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725002927
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