Host-specific response to HCV infection in the chimeric SCID-beige/Alb-uPA mouse model: role of the innate antiviral immune response.

Host-specific response to HCV infection in the chimeric SCID-beige/Alb-uPA mouse model: role of the innate antiviral immune response.

The severe combined immunodeficiency disorder (SCID)-beige/albumin (Alb)-urokinase plasminogen activator (uPA) mouse containing a human-mouse chimeric liver is currently the only small animal model capable of supporting hepatitis C virus (HCV) infection. This model was utilized to characterize the h...

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Main Authors: Kathie-Anne Walters, Michael A Joyce, Jill C Thompson, Maria W Smith, Matthew M Yeh, Sean Proll, Lin-Fu Zhu, T J Gao, Norman M Kneteman, D Lorne Tyrrell, Michael G Katze
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.0020059
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https://doi.org/10.1371/journal.ppat.0020059

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