Multiparity induces persistent myocardial structural, functional and transcriptomic remodelling in mice

Multiparity induces persistent myocardial structural, functional and transcriptomic remodelling in mice

Abstract Pregnancy poses unique hemodynamic and metabolic demands on the heart. Recent data suggests that a history of multiple pregnancies may be associated with a late-term increased risk of heart failure with preserved ejection fraction (HFpEF), however, the mechanistic basis is unknown. We postu...

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Main Authors: Ruth R. Magaye, Bing H. Wang, Hongyi R. Liu, Shanae Bailey, Rithy Nuon, Sabrina Sutano, Michael Nyugen, Helen Kiriazis, Kyah Grigolon, Luchen Shan, William W. H. Ho, Fumihiko Takeuchi, Daniel G. Donner, David M. Kaye
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Multiparity
Hypertrophy
Fibrosis
HFpEF
Cardiac remodelling
Online Access:https://doi.org/10.1038/s41598-025-08248-z
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https://doi.org/10.1038/s41598-025-08248-z

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