Optimization of 6-(trifluoromethyl)pyrimidine derivatives as TLR8 antagonists

Optimization of 6-(trifluoromethyl)pyrimidine derivatives as TLR8 antagonists

Toll-like receptors (TLRs) are essential for the innate immune system as they recognize pathogen-associated molecular patterns and trigger immune responses. Overactivation of TLR8 by endogenous nucleic acids is associated with the development of autoimmune diseases and promotes inflammatory response...

Full description

Saved in:
Bibliographic Details
Main Authors: Benedik Nika Strašek, Talagayev Valerij, Matziol Troy, Dolšak Ana, Sosič Izidor, Weindl Günther, Wolber Gerhard, Sova Matej
Format: Article
Language:English
Published: Sciendo 2025-06-01
Series:Acta Pharmaceutica
Subjects:
toll-like receptors
tlr8 antagonists
autoimmune disorders
immunomodulation
pyrimidines
Online Access:https://doi.org/10.2478/acph-2025-0011
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.2478/acph-2025-0011

Similar Items