Neoadjuvant chemotherapy or chemoradiotherapy plus sintilimab versus neoadjuvant chemoradiotherapy for locally advanced oesophageal squamous cell carcinoma: a study protocol of a multicentre, randomised, controlled, phase III trial (SCIENCE study)

Neoadjuvant chemotherapy or chemoradiotherapy plus sintilimab versus neoadjuvant chemoradiotherapy for locally advanced oesophageal squamous cell carcinoma: a study protocol of a multicentre, randomised, controlled, phase III trial (SCIENCE study)

Introduction Oesophageal squamous cell carcinoma (ESCC) is a globally challenging digestive tract malignancy with poor prognosis and limited treatment options. Early-stage ESCC is often asymptomatic, leading to a late-stage diagnosis in many cases. Neoadjuvant therapy combined with surgery is the st...

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Main Authors: Haining Zhou, Qiang Fang, Yongtao Han, Long Liang, Peng Tang, Lin Peng, Wenwu He, Yehan Zhou, Jiahua Lv, Xuefeng Leng, Hansong Bai, Tongchen Hu, Wenguang Xiao, Guangyuan Liu, Kangning Wang, Yunxiang Qi, Xiumei Zheng, Haomiao Qing, Yungchang Chen, Wenjing Xie
Format: Article
Language:English
Published: BMJ Publishing Group 2025-06-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/15/6/e095828.full
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https://bmjopen.bmj.com/content/15/6/e095828.full

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