Killing arthritogenic fibroblast-like synoviocytes: an example using cytotoxic aptamers binding nucleolin
Abstract “Pauci-immune” and “fibroblast-rich” synovial pathotypes are predictors of resistance to multi-drug immunosuppression. For these “difficult-to-treat” (D2T) endotypes of rheumatoid arthritis (RA), depletion of arthritogenic fibroblast-like synoviocytes (FLS) has emerged as promising treatmen...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-07-01
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| Series: | Arthritis Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13075-025-03618-4 |
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