Evaluating respiratory depression after methadone administration in surgical patients: protocol for a systematic review and meta-analysis

Introduction Methadone has emerged as a promising option for perioperative pain management, primarily due to its rapid onset of action and prolonged duration of effect, which provides sustained analgesic benefits. Despite its clinical advantages and minimal reported risks for postoperative respirato...

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Bibliographic Details
Main Authors: Guido Mazzinari, Juan P. Cata, Eduardo Nunez-Rodriguez, Sarah Lumsden, Kate J. Krause, Nicolas Cortes, Evan D. Kharasch
Format: Article
Language:English
Published: BMJ Publishing Group 2025-05-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/15/5/e099463.full
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