High-throughput virtual screening, identification and in vitro biological evaluation of novel inhibitors of PLK1 and NRP1

High-throughput virtual screening, identification and in vitro biological evaluation of novel inhibitors of PLK1 and NRP1

Overexpression of PLK1 and NRP1 correlate with enhanced proliferative activity in lung cancer cells, thus the development of dual-target PLK1/NRP1 inhibitors holds great therapeutic promise. In this study, five compounds (PLN 1-5) targeting both PLK1 and NRP1 were identified using a multi-step virtu...

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Bibliographic Details
Main Authors: Yang Xia, Yuting Chang, Lixia Guan, Yifei Geng, Qi Zhang, Xiaozhou Shen, Qian Bu, Miao-Miao Niu, Gaohua Han
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Polo-like kinase-1
neuropilin-1
lung cancer
dual-targeting inhibitors
virtual screening
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2025.2514677
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https://www.tandfonline.com/doi/10.1080/14756366.2025.2514677

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