Deubiquitinase OTUD7B stabilizes HNF4α to alleviate pressure overload-induced cardiac hypertrophy by regulating fatty acid oxidation and inhibiting ferroptosis

Deubiquitinase OTUD7B stabilizes HNF4α to alleviate pressure overload-induced cardiac hypertrophy by regulating fatty acid oxidation and inhibiting ferroptosis

Abstract Background Cardiac hypertrophy, a leading cause of heart failure, threatens global public health. Deubiquitinating enzymes (DUBs) are critical in cardiac pathophysiology by regulating protein stability, function, and degradation. Here, we investigated the role and regulating mechanism of ov...

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Bibliographic Details
Main Authors: Rujie Zheng, Wenjuan Song, Che Wang, Xiaoyu Du, Chunlei Liu, Xiaotong Sun, Chengzhi Lu
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Biomarker Research
Subjects:
Cardiac hypertrophy
Deubiquitinating enzyme
Ferroptosis
Fatty acid oxidation
Online Access:https://doi.org/10.1186/s40364-025-00766-2
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https://doi.org/10.1186/s40364-025-00766-2

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